Barcelona winger Malcom has received his first Brazil call-up while Marcelo and Gabriel Jesus have won recalls to face Argentina and Saudi Arabia in October.
Thiago Silva and Willian are the surprise omissions from Tite's latest 23-man squad with Douglas Costa also excluded due to a combination of injury and the ill-discipline of spitting at Sassuolo's Federico Di Francesco last weekend.
His absence paved the way for Malcom, 21, to be chosen as one of three uncapped players for the twin friendlies, despite featuring for just six minutes since signing for Barca.
While ankle and thigh problems ruined any chance of a Costa call-up, Tite confirmed his intention to speak with the Juventus forward about his widely condemned dismissal in Serie A.
"[Costa was not chosen] because of these two factors: the injury and the incident he had," the Brazil boss said.
"Incident or accident... I want to be careful with the adjective, I don't know how to put it. Because of a lack of discipline he's out.
"The priority now is the Selecao and those that have been summoned. We seek information. But the conversation with him will be at a later time."
Bordeaux defender Pablo and teenage Gremio goalkeeper Phelipe are also in contention to debut.
Pablo's inclusion presents him as a possible successor to Silva, the 33-year-old and fellow regular Willian both overlooked after forming part of the team that fell short of expectations at the World Cup.
Real Madrid left-back Marcelo goes some way to filling the gap in experience as he rejoins the squad alongside Manchester City trio Jesus, Danilo and Ederson, all of whom missed the September victories over United States and El Salvador.
Brazil squad in full:
Alisson (Liverpool), Ederson (Manchester City), Phelipe (Gremio); Danilo (Manchester City), Fabinho (Liverpool), Marcelo (Real Madrid), Marquinhos (PSG), Miranda (Inter), Eder Militao (Porto), Pablo (Bordeaux), Alex Sandro (Juventus); Arthur (Barcelona), Renato Augusto (Beijing Guoan), Casemiro (Real Madrid), Philippe Coutinho (Barcelona), Fred (Manchester United), Malcom (Barcelona), Richarlison (Everton), Walace (Hannover); Everton (Gremio), Roberto Firmino (Liverpool), Gabriel Jesus (Manchester City), Neymar (PSG).
|Davies released from Wales squad as Evans comes in|
|Mbappe on track to match Messi and Ronaldo, says Giuly|
|Coleman, Kipchoge and Lyles among IAAF Male World Athlete of the Year shortlist|
|Serena Williams will win slams again sooner or later, says Seles|
|You always want the best – Ter Stegen open to Neymar return|
|Xavi: My teams will never use Mourinho´s style|
|I knew what I got myself into - LeBron appreciates Lakers are a work in progress|
|Mourinho: Ronaldo loves United but he will want to score|
|Cooper completes Rebels move and takes parting shot at Reds coach Thorn|
|Bellerin amazed by ´born champion´ Ozil|
|Penguins, kangaroos and ´Stone Cold´ Steve Austin: Halloween comes early for Trail Blazers|
|Ronaldo gunning for United, Aguero targets double record - Champions League in Opta numbers|
|Ill Vardy couldn´t stomach penalty decision – Puel|
|LeBron´s Lakers lose again, Magic stun Celtics|
|Bartomeu: No Barca return for Neymar, Valverde contracted until 2020|
|Simmons and ´stimulating´ 76ers in NBA Finals mix, says Longley|
|Falcons heap further misery on Giants|
|Vidic hails Ronaldo as ultimate professional ahead of Old Trafford return|
|Warriors´ Cousins nearing NBA return|
|Pogba can´t do the basics – Souness criticises Man United star|
|Messi absence big blow for Barca as Icardi talks up Inter|
|´You can´t cry, that´s true´ – Ronaldo responds to Isco|
|Bartomeu: Barca still competitive without Messi|
|Bills RB McCoy remains in concussion protocol|
|Raiders place Marshawn Lynch on IR|
|Emery calm over title talk after another Arsenal win|
|Green: Warriors have to clean up defensively|
|Mariners say Bolt talks ongoing amid reports contract offer was rejected|
|Proud captain Ozil revels in Arsenal´s ´sexy football´|
|Puel angry over Holding handball|
|Cilic breezes through in Basel, Anderson fights back|
|Ingram: Four-game ban better than we expected|
|Raiders send Cooper to Cowboys for first-round pick|
|Arsenal 3 Leicester City 1: Outstanding Ozil inspires comeback win|
|World Series 2018: Three reasons why the Dodgers will win|
|Yarmolenko out for six months after Achilles surgery|
|World Series 2018: Three reasons why the Red Sox will win|
|Ozil eclipses Klinsmann to become Premier League´s most prolific German|
|Allegri expecting Old Trafford battle against Mourinho´s United|
|Bertens feared she did not belong in Kerber clash|
|Returning Ronaldo expecting ´tough´ game against Manchester United|
|Cristiano Ronaldo confident of clearing his name amid rape allegation|
|Osaka looking to learn from losing start in Singapore|
|Kovac expects tough test against AEK Athens|
|Whyte gives Chisora deadline over rematch|
|Spartak Moscow sack Massimo Carrera|
|Atletico Madrid confirm fresh injury issue for Gimenez|
|Dolberg extends Ajax contract after Real Madrid links|
|Ronaldo an example for Lukaku to follow|
|Bertens battles back to blast past Kerber|
|Ramos apologises for training ground fracas|
|Raikkonen should take heed of Alonso misfortune as F1 career winds down|
|Guardiola wants Manchester City fans to push team to Champions League glory|
|Isco not interested in departed Ronaldo - he didn´t want to be here|
|World Series 2018: Three storylines to watch in Red Sox-Dodgers|
|Neymar focus bad for football - PSG´s Maxwell|
|Marco Ianni charged by FA over Jose Mourinho touchline row|
|Stephens sees off Osaka in see-saw Singapore battle|
|I´m happy at Manchester United - Mourinho dismisses Real Madrid reports|
|Semenya and Asher-Smith head IAAF Female World Athlete of the Year shortlist|
|Mandzukic to miss Manchester United trip|
|I turned down Manchester United to return to Juventus - Bonucci|
|Sanchez out of Manchester United´s clash with Juventus|
|Australia make Short work of run chase in T20 win|
|Brotherly g-love! Tommy Fury follows Tyson into the pros|
|Ozil´s international retirement can help Arsenal - Emery|
|If you sack Lopetegui, you have to sack us all – Isco|
|Lopetegui defiant amid Real Madrid sack reports|
|Sri Lanka spinner Herath to retire after Galle Test|
|Ronaldo returns for Old Trafford welcome amid disquieting noise|